AG Löhning: "T helper cells have a quantitative memory for cytokine expression"

Publication in the journal "Immunity"

The group of Max Löhning (deputy director RCIS) found out that T helper cells produce different amounts of a certain cytokine. Some T helper cells secrete high amounts of this immune messenger and others produce only low quantities. Individual T helper cells acquire a stable quantitative memory for cytokine expression, i.e. in later reactivations; they always produce a similar amount of the given cytokine again, resulting in a stable heterogeneity within a population of differentiated T helper cells. 

Please find detailed information here.

(Helmstetter et al., 2015, Immunity 42, 108–122 January 20, 2015)

Contact

Prof. Dr. Max Löhning

Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie
Charité – Universitätsmedizin Berlin
Deutsches Rheuma-Forschungszentrum 
phone: +49 30 2846 0760