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AG Löhning: "T helper cells have a quantitative memory for cytokine expression"

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Publication in the journal "Immunity"

The group of Max Löhning (deputy director RCIS) found out that T helper cells produce different amounts of a certain cytokine. Some T helper cells secrete high amounts of this immune messenger and others produce only low quantities. Individual T helper cells acquire a stable quantitative memory for cytokine expression, i.e. in later reactivations; they always produce a similar amount of the given cytokine again, resulting in a stable heterogeneity within a population of differentiated T helper cells. 

Please find detailed information here.

(Helmstetter et al., 2015, Immunity 42, 108–122 January 20, 2015)


Prof. Dr. Max Löhning

Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie
Charité – Universitätsmedizin Berlin
Deutsches Rheuma-Forschungszentrum 
phone: +49 30 2846 0760

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